SGR Research Group

Role of TGF-β and oxidative stress in human pathologies

Workshop

Redox Biology in Health and Disease
June 27-28, 2023 | Faculty of Medicine and Health Sciences (University of Barcelona)

Presentation

Transforming growth factor-beta (TGF-β) is a cytokine that regulates tissue homeostasis and is dysregulated in various human pathologies. Our SGR group studies alterations in the signaling pathway of this cytokine, which is overactivated in two large groups of human pathologies: a) Liver cancer, particularly due to its role in invasion and metastasis; b) Cardiovascular genetic diseases related to connective tissue, in particular aortic aneurysm in Marfan syndrome (MFS) and aortic stenosis and heart disease in Williams-Beuren syndrome (WBS).

In recent years, we have progressed in the study of the TGF-β signaling pathway and have identified oxidative stress as a key element in the formation and progression of these pathologies. We are also testing new therapeutic tools to inhibit TGF-β hypersignaling. We want to advance in: i) the role of TGF-β and oxidative stress in the tumor microenvironment; ii) discover new targets related to TGF-β and redox stress in the pathogenesis of both aortopathies.

Objectives

Role of TGF-β, NADPH oxidases and oxidative stress on the liver tumor microenvironment:

1.1 Primary tumors: hepatocellular carcinoma and cholangiocarcinoma.
1.2 Liver metastasis, both intrahepatic and extrahepatic, focused on melanoma.

 

New TGF-β-based targets onto redox stress effectors in the pathogenesis of the aortopathy:

2.1. To identify additional sources of ROS in the progression of the aortopathy in Marfan Syndrome (MFS) and Williams-Beuren syndrome (WBS): focus on xanthine oxidoreductase and role of uric acid as pro-oxidant or antioxidant.
2.2. To apply new pharmacological therapies interfering to redox stress ameliorating the cognitive and cardiovascular injuries occurring in both diseases.

Staff Scientists

Isabel Fabregat PhD (IF)
Isabel Fabregat PhD (IF)

Research professor at IDIBELL-CIBERehd, coordinator of the team at IDIBELL/HUB/ICO.

Gustavo Egea PhD (GE)
Gustavo Egea PhD (GE)

Full professor at University of Barcelona (UB) and investigator at IDIBAPS. Coordinator of the team at UB/IDIBAPS.

 Àngels Fabra PhD (AF)
Àngels Fabra PhD (AF)

Research professor at IDIBELL.

Victoria Campuzano PhD (VC)
Victoria Campuzano PhD (VC)

Tenure professor at University of Barcelona (UB) and investigator at IDIBAPS-CIBERer.

Emilio Ramos PhD MD (ER)
Emilio Ramos PhD MD (ER)

Tenure professor at University of Barcelona and head of the Liver Surgery Unit, Bellvitge University Hospital (HUB). Investigator at IDIBELL-CIBERehd.

Teresa Serrano PhD MD (TS)
Teresa Serrano PhD MD (TS)

tenure professor at University of Barcelona (UB) and specialist physician, Service of Anatomical Pathology, Bellvitge University Hospital (HUB). Investigator at IDIBELL-CIBERehd.

Mariona Calvo MD (MC)
Mariona Calvo MD (MC)

Staff oncologist at the Medical Oncology Department in the Catalan Institute of Oncology (ICO). Investigator at IDIBELL.

Postdoctoral Investigators

Isaac Rodríguez-Rovira (IR-R)
Isaac Rodríguez-Rovira (IR-R)

UB-IDIBAPS.

Predoctoral Investigators

Rut Espinosa (RE)
Rut Espinosa (RE)

IDIBELL-CIBERehd.

Josep Amengual (JA)
Josep Amengual (JA)

IDIBELL-CIBERehd.

Ana Cantos (AC)
Ana Cantos (AC)

IDIBELL-CIBERehd.

Gemma Gofaus (GG)
Gemma Gofaus (GG)

IDIBELL-CIBERehd.

Research Assistants

Esther Bertran PhD (EB)
Esther Bertran PhD (EB)

IDIBELL-CIBERehd.

Antonia Vinyals (AV)
Antonia Vinyals (AV)

IDIBELL.

Maria Encarnación Palomo (MEP)
Maria Encarnación Palomo (MEP)

UB.

External Collaborators

  • Javier Vaquero and Ester González-Sánchez, Cancer Research Center (CIC/CSIC), University of Salamanca and CIBERehd. Salamanca, Spain.
  • Aránzazu Sánchez and Blanca Herrera, Complutense University of Madrid and CIBERehd. Madrid, Spain.
  • Luz Martínez-Chantar. CIC Biogune, Derio (Bizkaia), Spain.
  • Francesc Jiménez-Altayó. Autonomous University of Barcelona. Bellaterra, Spain
  • Artur Evangelista, Unidad Marfan, Hospital Valle Hebrón. Barcelona, España.
  • Alberto Forteza, Unidad Marfan, Hospital Puerta de Hierro. Madrid, España.
  • Gianluigi Giannelli, National Institute of Gastroenterology, “S. de Bellis” Research Hospital. Castellana Grotte (BA), Italy.
  • Cédric Coulouarn, Inserm, University of Rennes.  France.
  • Julie Le Merrer, University of Tours. France.
  • Jean-Luc Morel, University of Bordeaux. France.
  • Susanna Pietropaolo, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine. France.
  • Diego Calvisi. University of Regensburg. Germany.
  • Steven Dooley. University Medical Center Mannheim, Heidelberg University. Mannheim, Germany.
  • Wolfgang Mikulits, Medical University of Vienna. Austria.
  • Ulla G Knauss. Conway Institute, University College Dublin. Ireland.
  • Bart Loeys and Aline Verstraeten, UZA/UA Center of Medical Genetics. Antwerpen, Belgium.
  • Baptiste Lacoste, Ottawa Hospital Research Institute. Canada.
  • Fabrice Dabertrand, University of Colorado School of Medicine. Aurora, CO, USA.
  • Elizabeth E. Crouch, University of California San Francisco (UCSF). USA.
  • Amaia Lujambio, Icahn School of Medicine at Mount Sinai. New York, USA.