Current projects

Oxidative stress-based mechanisms and associated therapeutic effects in the cognitive and cardiovascular phenotypes in Williams-Beuren syndrome. PI: Victoria Campuzano. Funding organization: Ministerio de Ciencia e Innovación. # PID2021-124799OB-I00. Duration:2023-2025.

Deciphering the role of the NADPH oxidase NOX4 in hepatocellular carcinoma: relevance in tumor cells and stroma and cross-talk with the TGF-beta pathway. PI: Isabel Fabregat. Ministerio de Ciencia e Innovación. # PID2021-122551OB-I00. Duration:1-9-2022 – 31-8-2025. 

Towards a precision medicine using TGF-β inhibitors in hepatocellular carcinoma and cholangiocarcinoma. PI: Isabel Fabregat. Fundación Asociación Española Contra el Cáncer (AECC). # PRYGN211279FABR. Duration: 1-12-2021 – 30-11-2024. 

Studying senescence to improve vascular and cognitive dysfunction in Williams Syndrome. PI: Victoria Campuzano. Funding organization: Fundation Autour des Williams (France) Duration: 2022-2023. 

Patogénesis del aneurisma aórtico y estrés oxidativo en el síndrome de Marfan. PI: Gustavo Egea.  Funding organization: Ministerio de Ciencia e Innovación. # PID2020-113634RB-C2. Duration: 09/2021al 08/2024.

Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche. PI: Isabel Fabregat. Fundación Ramón Areces. # CIVP20A6593. Duration: 12-5-2021 – 11-5-2024.

Last 10 years publications

Espinosa-Sotelo R, Fusté NP, Peñuelas-Haro I, Alay A, Pons G, Almodóvar X, Albaladejo J, Sánchez-Vera I, Bonilla-Amadeo R, Dituri F, Serino G, Ramos E, Serrano T, Calvo M, Martínez-Chantar ML, Giannelli G, Bertran E, Fabregat I. Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma. Redox Biol. 2023 Sep;65:102818. doi: 10.1016/j.redox.2023.102818.

Peñuelas-Haro I, Espinosa-Sotelo R, Crosas-Molist E, Herranz-Itúrbide M, Caballero-Díaz D, Alay A, Solé X, Ramos E, Serrano T, Martínez-Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression. Hepatology. 2023 Aug 1;78(2):416-433. doi: 10.1002/hep.32702. 

Rodríguez-Rovira I, López-Sainz A, Palomo-Buitrago ME, Pérez B, Jiménez-Altayó F, Campuzano V, Egea G. Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome. Int J Mol Sci. 2023 Jul 10;24(14):11293. doi: 10.3390/ijms241411293.

Abdalla N, Tobías-Baraja E, Gonzalez A, Garrabou G, Egea G, Campuzano V. Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome  Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12):10071. doi: 10.3390/ijms241210071.

Abdalla N, Ortiz-Romero P, Rodriguez-Rovira I, Pérez-Jurado LA, Egea G, Campuzano V. The Combined Treatment of Curcumin with Verapamil Ameliorates the Cardiovascular  Pathology in a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Feb 7;24(4):3261. doi: 10.3390/ijms24043261.

Rodríguez-Rovira I, Arce C, De Rycke K, Pérez B, Carretero A,  Arbonés M, Teixidò-Turà G, Gómez-Cabrera MC, Campuzano V, Jiménez-Altayó F, Egea G. Allopurinol blocks aortic aneurysm in a mouse model of Marfan syndrome via  reducing aortic oxidative stress. Free Radic Biol Med. 2022 Nov 20;193(Pt 2):538-550. doi:  10.1016/j.freeradbiomed.2022.11.001. 

Arce C, Rodríguez-Rovira I, De Rycke K, Durán K, Campuzano V, Fabregat I, Jiménez-Altayó F, Berraondo P, Egea G. Anti-TGFβ (Transforming Growth Factor β) Therapy With Betaglycan-Derived P144 Peptide Gene Delivery Prevents the Formation of Aortic Aneurysm in a Mouse Model of Marfan Syndrome. Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):e440-e452. doi: 10.1161/ATVBAHA.121.316496. 

Herranz-Itúrbide M, Peñuelas-Haro I, Espinosa-Sotelo R, Bertran E, Fabregat I. The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease. Cells. 2021 Sep 3;10(9):2312. doi: 10.3390/cells10092312

Egea G, Jiménez-Altayó F, Campuzano V. Reactive Oxygen Species and Oxidative Stress in the Pathogenesis and Progression of Genetic Diseases of the Connective Tissue. Antioxidants (Basel). 2020 Oct 19;9(10):1013. doi: 10.3390/antiox9101013.

Caballero-Díaz D, Bertran E, Peñuelas-Haro I, Moreno-Càceres J, Malfettone A, López-Luque J, Addante A, Herrera B, Sánchez A, Alay A, Solé X, Serrano T, Ramos E, Fabregat I. Clathrin switches transforming growth factor-β role to pro-tumorigenic in liver cancer. J Hepatol. 2020 Jan;72(1):125-134. doi: 10.1016/j.jhep.2019.09.012. 

López-Luque J, Bertran E, Crosas-Molist E, Maiques O, Malfettone A, Caja L, Serrano T, Ramos E, Sanz-Moreno V, Fabregat I.  Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition. Cancer Lett. 2019 Nov 1;464:15-24. doi: 10.1016/j.canlet.2019.08.011.

Anna-Maria Siegert, Gerardo García Díaz-Barriga, Anna Esteve-Codina, Darya Gorbenko del Blanco, Jordi Alberch, Simon Heath, María Galán and Gustavo Egea (2019). Impact of FBN1 3’UTR mutation in the aortic aneurysm in Marfan syndrome through an endoplasmic reticulum stress molecular mechanism. *Biochim Biophys Acta-Mol Basis Dis. 2018; 1865(1):107-114. doi: 10.1016/j.bbadis.2018.10.029.

Jiménez-Altayó F, Meirelles T, Crosas-Molist E, Sorolla MA, Del Blanco DG, López-Luque J, Mas-Stachurska A, Siegert AM, Bonorino F, Barberà L, García C, Condom E, Sitges M, Rodríguez-Pascual F, Laurindo F, Schröder K, Ros J, Fabregat I, Egea G. Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm. Free Radic Biol Med. 2018 Apr;118:44-58. doi: 10.1016/j.freeradbiomed.2018.02.023. 

Siegert AM, Serra-Peinado C, Gutiérrez-Martínez E, Rodríguez-Pascual F, Fabregat I, Egea G. Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome. Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):554-562. doi: 10.1016/j.bbadis.2017.11.015. 

Crosas-Molist E, Bertran E, Rodriguez-Hernandez I, Herraiz C, Cantelli G, Fabra À, Sanz-Moreno V, Fabregat I. The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination. Oncogene. 2017 May 25;36(21):3002-3014. doi: 10.1038/onc.2016.454. 

Moreno-Càceres J, Mainez J, Mayoral R, Martín-Sanz P, Egea G, Fabregat I. Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1. FEBS J. 2016 Apr;283(7):1300-10. doi: 10.1111/febs.13669. 

Cepeda EB, Dediulia T, Fernando J, Bertran E, Egea G, Navarro E, Fabregat I. Mechanisms regulating cell membrane localization of the chemokine receptor CXCR4 in human hepatocarcinoma cells. Biochim Biophys Acta. 2015 May;1853(5):1205-18. doi: 10.1016/j.bbamcr.2015.02.012. 

Crosas-Molist E, Meirelles T, López-Luque J, Serra-Peinado C, Selva J, Caja L, Gorbenko Del Blanco D, Uriarte JJ, Bertran E, Mendizábal Y, Hernández V, García-Calero C, Busnadiego O, Condom E, Toral D, Castellà M, Forteza A, Navajas D, Sarri E, Rodríguez-Pascual F, Dietz HC, Fabregat I, Egea G. Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):960-72. doi: 10.1161/ATVBAHA.114.304412. 

Moreno-Càceres J, Caja L, Mainez J, Mayoral R, Martín-Sanz P, Moreno-Vicente R, Del Pozo MÁ, Dooley S, Egea G, Fabregat I. Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17. Cell Death Dis. 2014 Jul 17;5(7):e1326. doi: 10.1038/cddis.2014.294.

Bertran E, Crosas-Molist E, Sancho P, Caja L, Lopez-Luque J, Navarro E, Egea G, Lastra R, Serrano T, Ramos E, Fabregat I. Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells. Hepatology. 2013 Dec;58(6):2032-44. doi: 10.1002/hep.26597.